化合物BMS-986242 T9164

Product Introduction
Bioactivity


英文名: BMS-986242

描述: BMS-986242 是具有口服具有活力、强效的、选择性的 indoleamine-2,3-dioxygenase 1 抑制剂，可用于研究癌症。

体外活性: BMS-986242 is more prone to oxidative metabolism and less susceptible to glucuronidation. BMS-986242 exhibts IC50>25 μM for all targets except nAChR a1 (IC50=12.3 μM) and nAChR a7 (IC50>6 μM with ～20 % max inhibition).

体内活性: BMS-986242 (3~30 mg/kg; p.o.; 0~24 hours) shows dose-proportional exposure and a statistically significant reduction in kynurenine concentration in the tumor at all three doses

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 250 mg/mL (608.41 mM)


关键字: glucuronidation | potent | Indoleamine 2,3-Dioxygenase (IDO) | cancer | Inhibitor | BMS 986242 | BMS-986242 | inhibit | active | selective | orally

相关产品: β-Lapachone | IDO1-IN-2 | PF-06840003 | GNF-PF-3777 | IDO-IN-3 | Kushenol E | IDO-IN-8 | IACS-8968 S-enantiomer | IDO1-IN-1 | IDO-IN-9

相关库: Drug Repurposing Compound Library | Anti-Cancer Metabolism Compound Library | Anti-Cancer Drug Library | Immuno-Oncology Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Active Compound Library | Metabolism Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途