化合物Sephin 1 T9174

Product Introduction
Bioactivity


英文名: Icerguastat

描述: Icerguastat (IFB-088) 是一种缺乏 α2-肾上腺素能活性的 Guanabenz 衍生物，是一种磷酸酶调节亚单位 PPP1R15A (R15A)的选择性抑制剂。它能够抑制 eIF2α 去磷酸化，从而延长保护反应。它具有抗朊病毒作用。

体外活性: Sephin1 dose and time dependently reduced PrPSc in different neuronal cell lines which were persistently infected with various prion strains. In addition, prion seeding activity was reduced in Sephin1-treated cells. Importantly, we found that Sephin1 significantly overcame the endoplasmic reticulum (ER) stress induced in treated cells, as measured by lower expression of stress-induced aberrant prion protein[1].

体内活性: In a mouse model of prion infection, intraperitoneal treatment with Sephin1 significantly prolonged survival of prion-infected mice. When combining Sephin1 with the neuroprotective drug metformin, the survival of prion-infected mice was also prolonged[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 200 mg/mL(1017.10 mM)


关键字: Sephin1 | Inhibitor | IFB088 | misfolding | Sephin-1 | prion | IFB 088 | stress | eIF2α | sclerosis | Icerguastat | Phosphatase | inhibit | protein

相关产品: Ginkgolic acid C17:1 | PTP1B-IN-4 | Ascomycin | AS1949490 | Trimyristin | DA-3003-1 | Tartaric acid disodium dihydrate | SPI-112 | Pentamidine | TPI-1

相关库: Drug Repurposing Compound Library | Glycometabolism Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Phosphatase Inhibitor Library | Inhibitor Library | Metabolism Compound Library | Preclinical Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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