化合物2,4-Thiazolidinedione, 5-[[5-[6-(4-acety T9235

Product Introduction
Bioactivity


英文名: GW604714X

描述: GW604714X (2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-) 是一种高度特异性的线粒体丙酮酸载体抑制剂，Ki<0.1 nM。它是一种线粒体呼吸抑制剂。它也能抑制质膜单羧酸转运体的 L-乳酸转运，但浓度比 MPC 的大 4 个数量级。

体外活性: Direct measurement of pyruvate transport into rat liver and yeast mitochondria confirmed that these agents inhibited the mitochondrial pyruvate carrier (MPC) with K(i) values <0.1 μM. Inhibitor titrations of pyruvate-dependent respiration by heart mitochondria gave values for the concentration of inhibitor binding sites (pmol per mg protein) and their K(i) (nM) of 56.0 and 0.057 nM for the more hydrophobic GW604714X. GW604714X inhibited l-lactate transport by the plasma membrane monocarboxylate transporter MCT1, but at concentrations more than four orders of magnitude greater than the MPC.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMF : 5 mg/mL(10.61 mM)
DMSO : 4 mg/mL (8.48 mM)


关键字: Inhibitor | mitochondrial respiration | Mitochondrial Metabolism | GW604714X | Parkinson's Disease | MCT1 | pyruvate | Alzheimer's Disease | GW-604714X | inhibit | MPC

相关产品: Genistein 8-c-glucoside | L-2-Hydroxyglutaric acid disodium | CCI-006 | 4-methyl-6-phenyl-2H-pyranone | VK-28 | L-Histidine | Mitochonic acid 5 | α-Lipoic Acid | Glibenclamide | THP104c

相关库: Anti-Aging Compound Library | Mitochondria-Targeted Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Cuproptosis Compound Library | Metabolism Compound Library | Reprogramming Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途