化合物SBC-115337 T9276

Product Introduction
Bioactivity


英文名: SBC-115337

描述: SBC-115337 是苯并呋喃化合物，也是 PCSK9抑制剂 (IC50:0.5 μM) 。

体外活性: The potent compound (SBC-115,337) showed an IC50 of 0.6 μM measured in an in vitro ELISA assay to monitor the effect of PCSK9 binding to the recombinant LDLR. All the investigated compounds exhibited no effect on the synthesis, processing and secretion of PCSK9. Compound SBC-115,337 at 1.2 μM induced more than tenfold upregulation of LDLR in HepG2 cells with respect to the control, increased uptake of fluorescently labeled DiI-LDL and lowered LDL-c levels in mice fed a high-fat diet.[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 6 mg/mL (12.67 mM)


关键字: SBC115337 | Serine endopeptidases | benzofuran | LDLR | Threonine proteases | SBC 115337 | SBC-115337 | Ser/Thr Protease | inhibit | Inhibitor | recombinant | potent | DiI-LDL | Serine proteases | HepG2

相关产品: Fasudil | HTH-01-091 | PCSK9-IN-10 | CID 2011756 | 1-NM-PP1 | Cetraxate hydrochloride | WNK-IN-11 | Upamostat | CID-797718 | FOY 251

相关库: Cell Cycle Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Kinase Inhibitor Library | Inhibitor Library | Metabolism Compound Library | Protease Inhibitor Library | NO PAINS Compound Library | Bioactive Compound Library

化合物SBC-115337 T9276信息由TargetMol中国为您提供，如您想了解更多关于化合物SBC-115337 T9276报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途