化合物HM43239 T9428
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mL | 2294874-49-8 | ¥1,370.00 | 询底价 |
100 mg | 2294874-49-8 | ¥6,480.00 | 询底价 |
25 mg | 2294874-49-8 | ¥3,250.00 | 询底价 |
50 mg | 2294874-49-8 | ¥4,650.00 | 询底价 |
5 mg | 2294874-49-8 | ¥1,080.00 | 询底价 |
1 mg | 2294874-49-8 | ¥445.00 | 询底价 |
10 mg | 2294874-49-8 | ¥1,680.00 | 询底价 |
Product Introduction
Bioactivity
英文名: HM43239
描述: HM43239 是一种具有口服活性和选择性 FLT3抑制剂,IC50值为 1.1 nM (FLT3 野生型)、1.8 nM (FLT3 ITD 突变型) 和 1.0 nM (FLT3 D835Y 突变型)。HM43239 作为可逆的 I 型抑制剂直接抑制 FLT3 的激酶活性,并调节 p-STAT5, p-ERK SYK, JAK1/2 和 TAK1。HM43239 抑制白血病细胞的增殖并诱导其凋亡 (apoptosis)。
体外活性: HM43239 potently inhibits the growth of acute myeloid leukemia cell lines harboring FLT3 ITD mutation like MV4-11 (IC 50 : 1.3 nM), MOLM-13 (IC 50 : 5.1 nM), and MOLM-14 (IC 50 : 2.9 nM). Besides, HM43239 inhibits KG1a cells (CD34+/CD38- cells) proliferation [1]. HM43239 induces the caspase 3/7-dependent apoptosis of leukemic stem cell (LSC) marker-expressing KG1a cells (CD34+/CD38- cells) [1]. HM43239 potently inhibits phosphorylation of SYK, STAT3, and STAT5 in KG1a cells [3].
体内活性: HM43239 exhibits the excellent dose proportional antitumor activity in mouse models xenografted with both MV4-11 and MOLM-13 cell lines without any significant toxicity [1]. HM43239 prolongs survival in FLT3 ITD/TKD double mutated xenograft mouse models [3].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 50 mg/mL (99.79 mM)
关键字: HM 43239 | HM-43239 | HM43239
相关产品: Cediranib | TG-46 | AC710 | UNC2025 | UNC2541 | JI6 | Sorafenib tosylate | AMG 925 | Cabozantinib hydrochloride | BMS-2
相关库: Drug Repurposing Compound Library | Angiogenesis related Compound Library | Anti-Cancer Drug Library | Clinical Compound Library | Anti-Cancer Clinical Compound Library | Inhibitor Library | Kinase Inhibitor Library | Tyrosine Kinase Inhibitor Library | Anti-Cancer Active Compound Library | NO PAINS Compound Library
化合物HM43239 T9428信息由TargetMol中国为您提供,如您想了解更多关于化合物HM43239 T9428报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途