ZZW-115 T9429

Product Introduction
Bioactivity


英文名: ZZW-115

描述: ZZW-115 是一种有效的 NUPR1抑制剂，Kd 为 2.1 μM。ZZW-115是三氟拉嗪(TFP)的衍生物。ZZW-115显示出剂量依赖性肿瘤消退，无神经系统副作用，主要通过坏死和凋亡诱导细胞死亡。

体外活性: ZZW-115 (0.1-33 μM; 72 hours) effectively kills cancer cells, with an IC 50 in the range of 0.84 μM (ANOR) to 4.93 μM (HN14) [1]. ZZW-115 (0-100 μM; 24-72 hours) is efficient to kill these tumor cells with an IC 50 in the range of 0.42 μM (Hep2G cells) to 7.75 μM (SaOS-2 cells) [1]. ZZW-115 induces pancreatic cell death by necrosis and apoptosis. ZZW-115 treatment induces a decrease in ATP production and induces a ROS overproduction [1]. LDH release is significantly higher in ZZW-115-treated cells (MiaPaCa-2, 02-063, LIPC, Foie8b, and HN14 cells) than in control cells in a concentration-dependent manner. Similarly, caspase 3/7 activity is also greater in ZZW-115-treated cells. These experiments demonstrated that ZZW-115 exerted both pronecrotic and proapoptotic effects [1]. Cell Viability Assay [1] Cell Line: ANOR cells, MiaPaCa-2, 02-063, 01008, LIPC, 02136, HN01,01046, AOIPC, Foie8b, HN14 cells Concentration: 0.1- 33 μM Incubation Time: 72 hours Result: Was efficient in killing cancer cells, with an IC 50 in the range of 0.84 μM (ANOR) to 4.93 μM (HN14). Cell Proliferation Assay [1] Cell Line: U87, A375, U2OS, SaOS-2, HT29, SK-CO-1, LS174T, H1299 and H358, HepG2, PC3, THP-1, Daudi, Jurkat and MDA-MB-231 cells Concentration: 0-100 μM Incubation Time: 24 or 72 hours Result: Was efficient to kill these tumor cells with an IC 50 in the range of 0.42 μM (Hep2G cells) to 7.75 μM (SaOS-2 cells).

体内活性: ZZW-115 (0.5-5 mg/kg; injection; daily for 30 days) inhibits the pancreatic xenografted tumors growth [1]. ZZW-115 (5 mg/kg for 30 days; immunocompetent C57BL/6 mice were orthotopically implanted with Panc02 cells) treatment shows the tumor size is almost unmeasurable in some cases [1]. Animal Model: NMRI-Foxn1nu/Foxn1nu mice (nude mice) xenografted with MiaPaCa-2 cells [1] Dosage: 5, 2.5, 1.0, or 0.5 mg/kg Administration: Injection, daily for 30 days Result: When the mice were injected with 5 mg/kg ZZW-115, the tumors stopped growing a few days after treatment and their size decreased progressively, almost disappearing at the end of the treatment.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: ZZW-115 | ZZW 115 | ZZW115

ZZW-115 T9429信息由TargetMol中国为您提供，如您想了解更多关于ZZW-115 T9429报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途