4-羟雌甾酮 T9454

Product Introduction
Bioactivity


英文名: 4-Hydroxyestrone

描述: 4-Hydroxyestrone 是一种内源性雌激素代谢物，可强烈保护神经元细胞免受氧化损伤。

体外活性: Using immortalized mouse hippocampal neuronal cells as an in vitro model, 4-Hydroxyestrone, an estrone metabolite with little estrogenic activity, is found to have the strongest neuroprotective effect against oxidative neurotoxicity among 25 endogenous estrogen metabolites tested, and its protective effect is stronger than 17β-estradiol. Similarly, 4-Hydroxyestrone also exerts a stronger protective effect than 17β-estradiol against kanic acid-induced hippocampal oxidative damage in rats[1].

体内活性: 4-Hydroxyestrone also exerts a stronger protective effect than 17β-estradiol against kanic acid-induced hippocampal oxidative damage in rats. Neuroprotection by 4-hydroxyestrone involves increased cytoplasmic translocation of p53 resulting from SIRT1-mediated deacetylation of p53. Analysis of brain microsomal enzymes shows that estrogen 4-hydroxylation is the main metabolic pathway in the central nervous system[1].

存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Inhibitor | neuroprotective | Estrone | p53 | SIRT1 | Endogenous Metabolite | metabolite | inhibit | estrogenic | oxidative neurotoxicity | 4-OHE1 | 4-Hydroxyestrone | 4 Hydroxyestrone | 4Hydroxyestrone | deacetylation

相关产品: Segetalin B | CMP8 | Quinestrol | MPP hydrochloride | Fulvestrant | ARV-471 | Ethynyl estradiol | Estrogen receptor modulator 1 | Bazedoxifene acetate | 4-hydroxyestrone-4-methyl ether

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