化合物PY-60 T9566

Product Introduction
Bioactivity


英文名: PY-60

描述: PY-60 有效激活针对膜联蛋白 A2 (Kd = 1.4 µM) 的 YAP 转录活性。 PY-60 在能够通过增殖重塑表皮的成年动物中激活促增殖、依赖于 YAP 的转录程序。

体外活性: PY-60 robustly increased the levels of YAP-controlled transcripts (that is, ANRKD1, CYR61 and CTGF) in 293A cells and other human cell lines (that is, MCF10A, HEK293T, H69 and HaCaT), but did not augment the levels of YAP itself (YAP1). PY-60 induced luciferase activity in 293A-TEAD-LUC cells in the presence or absence of serum when cells were plated at high cell density with EC50s of 1.5 and 1.6 µM, respectively. PY-60 also promoted the association of YAP and TEAD proteins in cells in a dose-dependent manner and induced the nuclear localization of YAP in response to increased cell density[1].

体内活性: PY-60 (10 uM) 显著促进了角质形成细胞及K14阳性前体细胞的扩增。由于单位皮肤长度上角质形成细胞数量的增加，PY-60 使表皮厚度大约增加了一倍[1]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 95 mg/mL (303.16 mM)


关键字: PY60 | PY-60 | PY 60

相关产品: Amcinonide | Hydrocortisone 17-butyrate | Timonacic | LCKLSL acetate | Hydrocortisone acetate | Dexamethasone acetate

相关库: Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途