化合物KL201 T9608
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mg | 302939-48-6 | ¥849.00 | 询底价 |
1 mL | 302939-48-6 | ¥2,190.00 | 询底价 |
50 mg | 302939-48-6 | ¥8,380.00 | 询底价 |
5 mg | 302939-48-6 | ¥1,980.00 | 询底价 |
100 mg | 302939-48-6 | ¥11,300.00 | 询底价 |
25 mg | 302939-48-6 | ¥5,970.00 | 询底价 |
10 mg | 302939-48-6 | ¥3,730.00 | 询底价 |
Product Introduction
Bioactivity
英文名: KL201
描述: KL201 是一种昼夜节律调制器,是 CRY1选择性的 稳定剂, 对 CRY2 没有稳定作用。KL201 延长了细胞和组织中的昼夜节律周期。
体外活性: KL201 causes dose-dependent lengthening of circadian period in Bmal1-dLuc reporter cells, and in cells with another circadian reporter Per2-dLuc. KL201 suppresses the intensity of Per2-dLuc reporter much more than that of Bmal1-dLuc while not affecting cellular viability[1]. KL201 binds to CRY1 in overlap with FBXL3, a subunit of ubiquitin ligase complex, and the effect of KL201 is blunted by knockdown of FBXL3[1]. KL201 lengthened circadian period and suppressed the intensity of Per2::Luc knockin reporter in mouse lung primary explants[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 250 mg/mL (643.87 mM)
关键字: CRY1 | Inhibitor | Per2-dLuc | FBXL3 | KL201 | inhibit | clock | circadian | cryptochrome | KL-201 | KL 201
相关库: Bioactive Compounds Library Max | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途