化合物ZW4864 free base T9642

Product Introduction
Bioactivity


英文名: ZW4864 free base

描述: ZW4864 free base 是口服有效的，选择性的 β catenin/ B-Cell lymphoma 9 蛋白-蛋白相互作用 (β catenin/BCL9 PPI) 抑制剂 (Ki= 0.76 μM, IC50= 0.87 μM)。

体外活性: ZW4864 free base (10~40 μM; 24 hours) decreases the expression of Axin2 and cyclin D1 proteins in SW480 and MBA-MD-231 cells. ZW4864 free base (10~40 μM; 72 hours; MCF10A, MDA-MB231 and MDA-MB-468 cells) selectively triggeres rapid apoptosis of triple-negative breast cancer cells with hyperactive β-catenin signaling while sparing normal mammary epithelial MCF10A cells[1].

体内活性: ZW4864 free base (20 mg/kg; p.o.) exhibits good pharmacokinetic properties with an oral bioavailability (F) of 83 %. ZW4864 free base effectively suppresses β-catenin target gene expression in the patient-derived xenograft mouse model. ZW4864 free base (90 mg/kg; p.o.) exhibits a variation in tumor growth in mice[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 90.0 mg/mL (157.7 mM)


关键字: ZW4864 free base | ZW-4864 | ZW 4864 | ZW4864

相关产品: Wnt/β-catenin agonist 4 | Isoquercetin | Windorphen | LF3 | G007-LK | Wnt pathway activator 1 | Adavivint | WIKI4 | Gliotoxin | EMT inhibitor-1

相关库: Anti-Cancer Metabolism Compound Library | Neuronal Differentiation Compound Library | Bioactive Compounds Library Max | Anti-Ovarian Cancer Compound Library | Inhibitor Library | Cytoskeletal Signaling Pathway Compound Library | PPI Inhibitor Library | Stem Cell Differentiation Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途