化合物 Patamostat T9670

Product Introduction
Bioactivity


英文名: Patamostat

描述: Patamostat (E-3123)是一种有效的蛋白酶抑制剂，对胰蛋白酶、纤溶酶和凝血酶具有显著抑制效果，其IC50值分别为39 nM、950 nM和1.9 μM。Patamostat可能在急性胰腺炎的发病机制和发展中发挥抑制作用。

体内活性: Patamostat (intravenous infusion) at 0.03-0.3 mg/kg in rats or at 0.3-3.0 mg/kg in rabbits reduces mortality after pancreatitis induction in a dose-dependent manner [1]. Patamostat (1.0-3.0 mg/kg; intravenous infusion) reduces the increases of serum trypsin and lipase activities in dogs with pancreatitis [1]. Patamostat (2 mg/kg per h; continuous infusion) improves almost all parameters, including mortality rate, serum and ascitic fluid amylase levels, plasma endotoxin and serum FDP levels, and distribution of lysosomal enzyme in male Wistar rats [2]. Animal Model: Male Wistar rats weighing about 350 g [2] Dosage: 2 mg/kg Administration: Continuous infusion per h for 1 h Result: Significantly improved the survival rate.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Patamostat

化合物 Patamostat T9670信息由TargetMol中国为您提供，如您想了解更多关于化合物 Patamostat T9670报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途