化合物CC-90001 T9688

Product Introduction
Bioactivity


英文名: CC-90001

描述: CC-90001 是口服有效的 c-Jun N 末端激酶选择性抑制剂。在基于细胞的模型中，CC-90001显示出对JNK1的选择性是JNK2的 12.9 倍。CC-90001在特发性肺纤维化方面有研究价值。

体外活性: CC-90001 is 12.9-fold more potent for JNK1 inhibition over JNK2 in knockout fibroblasts[1]. CC-90001 blocks LPS-induced c-jun phosphorylation (EC50 = 480 nM)[2].

体内活性: CC-90001 decreases multiple measures of lung collagen and reduces disease induced increases in α-SMA to nearly baseline levels in a house dust mite model of lung fibrosis[2]. CC-90001 (3 mg/kg b.i.d.) reduces the development of fibrosis which has been confirmed by a 48% reduction in collagen and a 53% reduction in α-smooth muscle actin (α-SMA) in a steatohepatitis model[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 125 mg/mL (388.90 mM)


关键字: CC90001 | kinase | IPF | CC 90001 | JNK | c-Jun | idiopathic | JNK1 | Inhibitor | N-terminal | inhibit | CC-90001 | fibrosis | pulmonary

相关产品: JTP10-△-R9 TFA | Dehydroglyasperin C | JNK-IN-7 | Ganoderic acid X | WHI-P258 | 6,4'-Dihydroxy-7-methoxyflavanone | Goshonoside F5 | Decursinol angelate | Desoxo-narchinol A | Loureirin B

相关库: Drug Repurposing Compound Library | Anti-Prostate Cancer Compound Library | Anti-Liver Cancer Compound Library | Anti-Cancer Drug Library | Bioactive Compounds Library Max | Kinase Inhibitor Library | Anti-Cancer Clinical Compound Library | Inhibitor Library | Orally Active Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途