化合物TAK-615 T9699

Product Introduction
Bioactivity


英文名: TAK-615

描述: TAK-615常用于研究肺纤维化，是一种LPA1受体的负变构调节剂。

体外活性: TAK-615 specifically binds to membranes expressing the human LPA1 receptor with estimated Kd high affinity of 1.7 ± 0.5 nM and Kd low affinity of 14.5 ± 12.1 nM. TAK-615 is only able to partically inhibit the LPA response (~40% at 10 μM with an IC50 of 23 ± 13 nM in β-arrestin assay; 60% at 10 μM, IC50 of 91 ± 30 nM in calcuim mobilisation assay). [1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 120 mg/mL (286.10 mM)


关键字: LPA1 | fibrosis | LPL Receptor | Lysophospholipid Receptor | modulator | TAK 615 | NAM | TAK-615 | TAK615 | inhibit | pulmonary | Inhibitor | allosteric | negative

相关产品: ONO-7300243 | LPA2 antagonist 2 | Tetradecyl Phosphonate | H2L5186303 | Radioprotectin-1 | 1-Oleoyl lysophosphatidic acid sodium | GRI977143 | AM095 | BMS-986020 | Ki16198

相关库: Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途