化合物DB2313 T9707

Product Introduction
Bioactivity


英文名: DB2313

描述: DB2313 (Carboximidamide) 是一种有效的转录因子 PU.1 抑制剂，IC50 为 14 nM。DB2313 破坏了 PU.1 与靶基因启动子的相互作用。DB2313 可诱导急性髓细胞性白血病 (AML) 细胞凋亡 (apoptosis)，并具有抗癌作用。

体外活性: DB2313 decreases PU.1 occupancy on E2f1, Junb, and Csf1r promoters in AML cells. DB2313 treatment leads to a profound decrease in the growth of PU.1 URE–/– acute myeloid leukemia (AML) cells (IC50 of 7.1 μM), while showing little effect on normal hematopoietic cells at similar concentrations. DB2313 treatment leads to a 3.5-fold increase in apoptotic cells in murine PU.1 URE–/– AML cells. DB2313 also leads to a significant decrease in clonogenicity in the second and third rounds of plating and a complete disruption of clonogenic capacity in the fourth and higher rounds of plating[1].

体内活性: DB2313 (17 mg/kg; i.p.; three times per week for 3 weeks) treatment decreases leukemia progression and results in increased survival in mice.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 3 mg/mL (4.2 mM)


关键字: DB-2313 | DB2313 | DB 2313

相关产品: RUNX-IN-2 | BIX02188 | TMI-1 | 1-beta-D-Arabinofuranosylthymine | Salinomycin sodium salt | (+)-Nortrachelogenin | Mivebresib | Sophoraflavanone G | Tubulin inhibitor 35 | ICCB280

相关库: Anti-Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Cancer Active Compound Library | Bioactive Compound Library

化合物DB2313 T9707信息由TargetMol中国为您提供，如您想了解更多关于化合物DB2313 T9707报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途