化合物SETDB1-TTD-IN-1 T9742

Product Introduction
Bioactivity


英文名: SETDB1-TTD-IN-1

描述: SETDB1-TTD-IN-1 是一种有效且选择性的 SET domain bifurcated protein 1 tandem tudor domain (SETDB1-TTD, Kd = 88 nM) 抑制剂。它可用于关于 SETDB1-TTD 的生物学功能和疾病关联的研究。

体外活性: SETDB1-TTD-IN-1 (2.5-40 μM) efficiently and dose-dependently stabilizes the SETDB1-TTD protein in HEK293T cells. SETDB1-TTD-IN-1 (2.5-40 μM; 24 h) significantly affected the expression of 72 genes in human acute monocytic leukemia THP-1 cells. SETDB1-TTD-IN-1 shows some activity for 53BP1 and JMJD2A, with Kds of 4.3 μM and 86 μM, respectively. SETDB1-TTD-IN-1 does not show activity against 14 of the 16 tested tudor domains (Kd>100 μM)[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 45 mg/mL (95.83 mM)


关键字: SETDB1TTDIN1 | SETDB1 TTD IN 1 | SETDB1-TTD-IN-1 | SETDB-1-TTD-IN-1

相关产品: UNC0321 | BAY-598 | UNC1215 | SNDX-5613 | GSK126 | MAK-683 hydrochloride | JQEZ5 | SGC0946 | BML-278 | EZH2-IN-15

相关库: Bioactive Compounds Library Max | Inhibitor Library | Epigenetics Compound Library | Histone Modification Compound Library | Bioactive Compound Library

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