化合物MP07-66 T9744

Product Introduction
Bioactivity


英文名: MP07-66

描述: MP07-66 是 FTY720 的一种类似物，没有免疫抑制作用。MP07-66通过破坏 SET-PP2A 复合物导致PP2A 重新激活。MP07-66在慢性淋巴细胞白血病中显示出良好的抗肿瘤作用。

体外活性: CLL cells were incubated with increasing concentrations of MP07-66 (0-16 μM) for 24 and 48 hours and then subject to annexin V–PI flow cytometry. The level of apoptosis reached 50% and 80%, at 24 hours and 48 hours, respectively, at a MP07-66 concentration as high as 16 μM, which paralleled PARP cleavage, a marker of caspase-dependent apoptosis. In addition, the phosphorylation status of PP2A targets, namely Akt, GSK-3, and SHP-1, was negatively affected by the treatment with MP07-66, triggering known downstream events promoting apoptosis, such as Mcl-1 degradation and caspase-3 activation[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 250 mg/mL (772.87 mM)


关键字: MP0766 | chronic lymphocytic leukemia | FTY720 analogue | Inhibitor | SET-PP2A complex | inhibit | immunosuppressive effects | MP-07-66 | MP07-66 | Phosphatase | MP07 66 | antitumor effects

相关产品: PTP1B-IN-2 | L-Ascorbic acid 2-phosphate magnesium | NSC 95397 | K-Ras G12C-IN-1 | F1063-0967 | LYP-IN-3 | PROTAC PTPN2 degrader-2 TFA | BTdCPU | Voclosporin | SC-43

相关库: Anti-Cancer Compound Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library | Metabolism Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途