羟芪巴脒 T9879

Product Introduction
Bioactivity


英文名: Hydroxystilbamidine

描述: Hydroxystilbamidine ((E)-hydroxystilbamidine) 是一种能够结合 DNA 和 RNA 的染料， 也被发现是细胞核糖核酸酶的强效抑制剂。

体外活性: Hydroxystilbamidine permits the recovery of mRNA after polysome released with Nonidet P-40 (NP-40). Sucrose gradient analysis of detergent-lysed postnuclear supernates is used to analyze the size distribution of NP-40-released polysomes. The heparin gradient shows some polyribosomes, whereas the Hydroxystilbamidine gradient shows a remarkably large peak of very heavy polyribosomes. This peak is obtained reproducibly if Hydroxystilbamidine is present before the addition of NP-40[1].

体内活性: Hydroxystilbamidine is an effective suppressor of the plaque-forming cell (PFC) response when given before sheep erythrocytes (SRBC) stimulation. Hydroxystilbamidine depresses the plaque response of the treated mice. Fewer PFC are observed in Hydroxystilbamidine-treated mice throughout the experiment, but the level of suppression decreases with time. By day 14, the number of PFC observed in both the Hydroxystilbamidine treated mice and the control group is essentially at the background level[2].

存储条件: keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : Insoluble


关键字: Hydroxystilbamidine

相关库: Bioactive Compounds Library Max | Bioactive Compound Library

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