化合物YM-244769 T9888

Product Introduction
Bioactivity


英文名: YM-244769

描述: YM-244769 (3-Pyridinecarboxamide, N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-) 是一种有效的 Na+/Ca2+ exchange 3 (NCX3) 抑制剂，IC50 为 18 nM。 YM-244769 对神经元和肾脏具有有效的保护作用。

体外活性: YM-244769 (0.3 or 1 μM) efficiently suppresses the hypoxia/reoxygenation-induced cell damage in SH-SY5Y cells treated with NCX1 antisense (i.e., SH-SY5Y cells primarily expressing NCX3) more than in those treated with NCX3 antisense (i.e., SH-SY5Y cells primarily expressing NCX1). YM-244769 (0.003-1 μM) inhibits the initial rates of 45 Ca 2+ uptake into NCX1, NCX2, and NCX3 transfectants with IC 50 values of 68±2.9, 96±3.5, and 18±1.0 nM, respectively, indicating that YM-244769 is approximately four to five times more selective to NCX3 than other isoforms[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 245 mg/mL (552.46 mM)


关键字: nicotinamide | Na+/Ca2+ exchange | neuroprotective | YM244769 | NCX3 | SH-SY5Y cells | YM-244769 | Inhibitor | anti-ischemic | inhibit | LLC-PK1 cells | Na+/Ca2+ Exchanger | YM 244769

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