化合物UCM-1336 T9935

Product Introduction
Bioactivity


英文名: UCM-1336

描述: UCM-1336 (3,3′-(Octylimino)bis[N-phenylpropanamide]) 是一种有效的 ICMT 抑制剂，IC50 为 2 μM，对参与 Ras 翻译后修饰的其他酶具有选择性。

体外活性: UCM-1336 significantly impairs the membrane association of the four Ras isoforms, leading to a decrease of Ras activity and to inhibition of Ras downstream signaling pathways. UCM-1336 induces cell death in a variety of Ras-mutated tumor cell lines and increases survival in an in vivo model of acute myeloid leukemia. Because ICMT inhibition impairs the activity of the four Ras isoforms regardless of its activating mutation, UCM-1336 surmounts many of the common limitations of available Ras inhibitors described so far[2].

体内活性: UCM-1336 显著抑制了小鼠中的胶质母细胞瘤生长，且未引起毒性反应[1]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 11 mg/mL (25.97 mM)


关键字: UCM 1336 | UCM1336 | UCM-1336

相关库: Bioactive Compounds Library Max | Inhibitor Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途