化合物BT173 T9953

Product Introduction
Bioactivity


英文名: BT173

描述: BT173 是一种新型的同源域相互作用蛋白激酶 2 (HIPK2) 抑制剂，通过抑制 TGF-β1/Smad3 通路减轻肾纤维化。

体外活性: BT173 strongly inhibited the ability of HIPK2 to potentiate the downstream transcriptional activity of Smad3 in kidney tubular cells. Binding of BT173 to HIPK2 did not inhibit HIPK2 kinase activity but rather, interfered allosterically with the ability of HIPK2 to associate with Smad3. In vitro, treatment with BT173 inhibited TGF-β1–induced Smad3 phosphorylation and Smad3 target gene expression in human renal tubular epithelial cells. [1]

体内活性: In vivo, administration of BT173 decreased Smad3 phosphorylation and mitigated renal fibrosis and deposition of extracellular matrix in unilateral ureteral obstruction and Tg26 mouse models of renal fibrosis [1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : Insoluble


关键字: BT173 | BT-173 | BT 173

相关库: Bioactive Compounds Library Max | Inhibitor Library | Kinase Inhibitor Library | PPI Inhibitor Library | TGF-beta/Smad Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途