原苏木素A TJS1779

Product Introduction
Bioactivity


英文名: Protosappanin A

描述: Protosappanin A (PTA) 是从苏木中分离得到的免疫抑制成分和主要联苯化合物，通过下调 JAK2和 STAT3的磷酸化，抑制 JAK2/STAT3依赖的炎症通路。

体外活性: Protosappanin A (PsA) and Protosappanin B (PsB) were identified from Sappan Lignum extracts. They showed activity against both S. aureus and MRSA with MIC or MIC50 at 64 (PsA) and 128 (PsB) mg/L alone. When they were used in combination with antibiotics, they showed the best synergy with amikacin and gentamicin with MIC50 (mg/L) of amikacin reduced more significantly from 32 to four (with PsA) and eight (with PsB), and the fractional inhibitory concentration index (FICI) ranged between 0.078 and 0.500 (FICI50 = 0.375). Moreover, the resistance of MRSA towards amikacin and gentamicin could be reversed by the Clinical and Laboratory Standards Institute criteria. The combined bactericidal mode could as well be synergy. PsA and PsB showed very low cytotoxicity in comparison with their promising activity against MRSA[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 225 mg/mL (826.45 mM)


关键字: inhibit | JAK | Inhibitor | Protosappanin A | STAT | Janus kinase

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相关库: JAK-STAT Compound Library | Anti-Liver Cancer Compound Library | Anti-Cancer Compound Library | Mitochondria-Targeted Compound Library | Selected Plant-Sourced Compound Library | NF-κB Signaling Compound Library | Membrane Protein-targeted Compound Library | Anti-Ovarian Cancer Compound Library | Kinase Inhibitor Library | Traditional Chinese Medicine Monomer Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途