金色酰胺醇酯 TJS2216

Product Introduction
Bioactivity


英文名: Aurantiamide acetate

描述: Aurantiamide acetate (Asperglaucide) 是抑制口服有活性的 cathepsin 选择性抑制剂，分离自 Portulaca oleracea L。它具有抗炎作用，可用于研究炎性相关疾病。

体外活性: Aurantiamide acetate decreases viability of U87 and U251 cancer cells in vitro when used at concentrations ranging from 10 to 100 μM. Aurantiamide acetate inhibited cysteine proteinases, in particular, cathepsin L and B with IC50 of 12 microM and 49 microM, respectively.

体内活性: Aurantiamide acetate reduces tumor growth when administered at a dose of 1 mg via intratumoral injection in a U87 mouse xenograft model. In the adjuvant-arthritic rat model, subcutaneously administered 10 mg/kg body weight of this compound suppressed hind paw swelling.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 55 mg/mL (123.73 mM)


关键字: Aurantiamide acetate | Inhibitor | cathepsin L | Piper aurantiacum | Aurantiamide Acetate | adjuvant-arthritic | Cathepsin | inhibit | Aurantiamide | inflammatory diseases

相关产品: 3-Epiursolic acid | ONO-5334 | MIV-247 | CA 074 | N-Ethylmaleimide | (RS)-Butyryltimolol | Leupeptin Hemisulfate | Cathepsin Inhibitor 1 | LY 3000328 | Tecovirimat

相关库: Anti-Inflammatory Traditional Chinese Medicine Compound Library | Marine Natural Product Library | Tobacco Monomer Library | Bioactive Compounds Library Max | Inhibitor Library | Traditional Chinese Medicine Monomer Library | Miao medicine Compound Library | Orally Active Compound Library | Traditional Mongolian Medicine Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途