独活内酯 TL0013
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mg | 2880-49-1 | ¥413.00 | 询底价 |
1 mL | 2880-49-1 | ¥919.00 | 询底价 |
25 mg | 2880-49-1 | ¥2,480.00 | 询底价 |
50 mg | 2880-49-1 | 面议 | 询底价 |
10 mg | 2880-49-1 | ¥1,470.00 | 询底价 |
2 mg | 2880-49-1 | ¥598.00 | 询底价 |
5 mg | 2880-49-1 | ¥993.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Heraclenin
描述: Heraclenin 是一种天然呋喃香豆素。它浓度依赖性的靶向激活的 T 细胞核因子 (NFAT) ,抑制人原代 T 细胞中 T 细胞受体介导的增殖。
体外活性: METHODS AND RESULTS:Heraclenin, a furocoumarin with an epoxide group in its side chain, was analyzed to see if it induced structural chromosome aberrations and sister-chromatid exchanges (SCEs) in human lymphocytes in vitro. The results were compared directly with those of imperatorin, which differs from Heraclenin only in lacking an epoxide group. An equally strong clastogenic effect was found for both Heraclenin and imperatorin: the number of metaphases with breaks was increased in both cases by approximately a factor of 6. Heraclenin produced a considerable dose-dependent increase in the SCE rate, i.e., by about 60 induced SCEs/metaphase, whereas imperatorin induced only about 4 SCEs/metaphase. CONCLUSIONS: The results are discussed with respect to the occurrence of structural aberrations, which are primarily due to the basic furocoumarin structure itself, whereas the large increase in the SCE rate produced by Heraclenin is most probably significantly influenced by its epoxide group.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 25 mg/mL (87.33 mM)
关键字: Heraclenin | inhibit | Inhibitor
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途