Neuropilin-1, Human, 重组蛋白 (aa 22-644, Avi & His), Biotinylated TMPJ-00355

Product Introduction
Bioactivity


英文名: Neuropilin-1 Protein, Human, Recombinant (aa 22-644, Avi & His), Biotinylated

描述: Neuropilin-1 (Npn-1, previously neuropilin; also CD304) is a 130 - 140 kDa type I transmembrane (TM) glycoprotein that regulates axon guidance and angiogenesis. Two homologues, Neuropilin-1 and Neuropilin-2, are identified. Neuropilin-1 binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. NRP1 expression is regulated in EC by tumor necrosis factor-alpha, the transcription factors dHAND and Ets-1, and vascular injury. NRP1 upregulation is positively correlated with the progression of various tumors.

存储条件: Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6~12 month

关键字: NRP-1 | CD 304 | NRPNP-1 | NRPNP 1 | CD-304 | NRP 1 | BDCA 4 | BDCA-4

Neuropilin-1, Human, 重组蛋白 (aa 22-644, Avi & His), Biotinylated TMPJ-00355信息由TargetMol中国为您提供，如您想了解更多关于Neuropilin-1, Human, 重组蛋白 (aa 22-644, Avi & His), Biotinylated TMPJ-00355报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途