FGFR2IIIc, Human, 重组蛋白 (hFc) TMPJ-00388
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
50 μg | TMPJ-00388 | ¥1,670.00 | 询底价 |
500 μg | TMPJ-00388 | ¥13,700.00 | 询底价 |
1 mg | TMPJ-00388 | ¥20,500.00 | 询底价 |
10 μg | TMPJ-00388 | ¥550.00 | 询底价 |
Product Introduction
Bioactivity
英文名: FGFR2IIIc Protein, Human, Recombinant (hFc)
描述: FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR2 acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Four distinct genes encoding closely related FGF receptors, FGF R1 - 4, are known. A frequent splicing event involving FGF R1 and 2 results in receptors containing all three Ig domains, referred to as the alpha isoform, or only IgII and IgIII, referred to as the beta isoform. Only the alpha isoform has been identified for FGF R3 and FGF R4. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.
存储条件: Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6~12 month
关键字: FGFR-2 | CD-332 | CD 332 | FGFR 2
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途