TRAIL R2/DR5/TNFRSF10B, Cynomolgus, 重组蛋白 (His) TMPJ-00430

Product Introduction
Bioactivity


英文名: TRAIL R2/DR5/TNFRSF10B Protein, Cynomolgus, Recombinant (His)

描述: TNFRSF10B is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. The adapter molecule FADD recruits caspase-8 to the activated receptor and is required for the apoptosis mediated by TNFRSF10B. TNFRSF10B is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. This single-pass transmembrane protein contains two cysteine-rich repeat units in its extracellular region, followed by a transmembrane segment and a cytoplasmic tail containing a typical “death domain”. TNFRSF10B expression is regulated by the tumor suppressor p53. It is also indicated that the activation of NF-kappa-B can be promoted by TNFRSF10B.

存储条件: Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6~12 month

关键字: DR-5 | TRICK-2 | TRAILR-2 | CD 262 | CD-262 | TRICK 2 | ZTNFR-9 | DR 5 | ZTNFR 9 | TRAILR 2

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