GUCY2C, Human, 重组蛋白 (His & Avi), Biotinylated TMPJ-00910

Product Introduction
Bioactivity


英文名: GUCY2C Protein, Human, Recombinant (His & Avi), Biotinylated

描述: GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family. GUCY2C cell surface expression is confined to luminal surfaces of the intestinal epithelium and a subset of hypothalamic neurons. The inaccessibility of GUCY2C in the apical membranes of polarized epithelial tissue, due to subcellular restriction of GUCY2C, creates a therapeutic opportunity to target metastatic lesions of colorectal origin which have lost apicalbasolateral polarization without concomitant intestinal toxicity. And that CAR-T cells targeting murine GUCY2C were effective against colorectal cancer metastatic to lung in the absence of intestinal toxicities. Human GUCY2C-targeted CAR that could potentially be employed in patients with GUCY2C-expressing gastrointestinal malignancies.

存储条件: Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6~12 month

GUCY2C, Human, 重组蛋白 (His & Avi), Biotinylated TMPJ-00910信息由TargetMol中国为您提供，如您想了解更多关于GUCY2C, Human, 重组蛋白 (His & Avi), Biotinylated TMPJ-00910报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途