SIRP alpha, Mouse, 重组蛋白 (MIgG2a) TMPJ-01182

Product Introduction
Bioactivity


英文名: SIRP alpha Protein, Mouse, Recombinant (MIgG2a)

描述: SIRPα is a type I transmembrane glycoprotein.It contains two Ig-like C1-type domains and one Ig-like V-type domain. Mouse SIRP alpha ECD shares 61%, 75%, 62%, 61%, and 59% aa sequence identity with human, rat, equine, bovine, and porcine SIRP alpha, respectively.SIRPα can express in various tissues, mainly on brain and myeloid cells, including macrophages, neutrophils, dendritic and Langerhans cells. It also can detect in neurons, smooth muscle and endothelial cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPα acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPα shows adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. SIRPα engagement generally produces a negative regulatory signal; it may mediate negative regulation of phagocytosis, mast cell activation and dendritic cell activation.

存储条件: Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6~12 month

关键字: SHPS 1 | SHPS-1 | Signal-Regulatory Protein a-1

SIRP alpha, Mouse, 重组蛋白 (MIgG2a) TMPJ-01182信息由TargetMol中国为您提供，如您想了解更多关于SIRP alpha, Mouse, 重组蛋白 (MIgG2a) TMPJ-01182报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途