HSC70, Human, 重组蛋白 (His) TMPY-02217

Product Introduction
Bioactivity


英文名: HSC70 Protein, Human, Recombinant (His)

描述: HSPA8, also known as HSC70, is a member of the heat shock protein family due to homology with other heat shock proteins. The heat shock protein 70 family is comprised of both heat-inducible and constitutively expressed members. The latter are called heat-shock cognate proteins. HSPA8 belongs to the heat-shock cognate subgroup. Members of the human heat-shock protein multigene family have several highly conserved proteins with structural and functional properties in common but vary in the extent of their inducibility in response to metabolic stress. HSPA8 is constitutively expressed and performs functions related to normal cellular processes. This protein binds to nascent polypeptides to facilitate correct protein folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during the transport of membrane components through the cell. Two alternatively spliced variants have been characterized to date. HSPA8 acts as a repressor of transcriptional activation. It inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Isoform 2 may function as an endogenous inhibitory regulator of HSC70 by competing with the co-chaperones. It also is an ATPase that works with Auxilin to remove clathrin-coated vesicles. In neurons, synaptojanin is also an important protein involved in vesicle uncoating.

存储条件: Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6~12 month

关键字: HSP 73 | HEL 33 | HSC 54 | LAP 1 | HSC-70 | HSC 71 | HSP-71 | HSPA-10 | HEL33 | HSC 70 | HSP 71 | HSPA 10 | NIP-71 | HSP-73 | HSC-54 | NIP 71 | HSC-71

HSC70, Human, 重组蛋白 (His) TMPY-02217信息由TargetMol中国为您提供，如您想了解更多关于HSC70, Human, 重组蛋白 (His) TMPY-02217报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途