CD16a, Human, 重组蛋白 (176 Phe, His) TMPY-02816

Product Introduction
Bioactivity


英文名: CD16a Protein, Human, Recombinant (176 Phe, His)

描述: The Fc receptor with low affinity for IgG (FCGR3, or CD16) is encoded by 2 nearly identical genes, FCGR3A and FCGR3B, resulting in tissue-specific expression of alternative membrane-anchored isoforms. FCGR3A, it is also known as CD16a, encodes a transmembrane protein expressed on activated monocytes/macrophages, natural killer (NK) cells, and a subset of T cells.CD16a / FCGR3A is a receptor expressed on NK cells that facilitates antibody dependent cellular cytotoxicity (ADCC) by binding to the Fc portion of various antibodies. CD16a / FCGR3A also has a broader function. CD16a / FCGR3A is directly involved in the lysis of some virus-infected cells and tumor cells by NK cells, independent of antibody binding. Cross-linking of CD16a / FCGR3A on NK cells resulted in increased intracellular Ca2+ levels and a cascade of biochemical events similar to those activated by the T cell receptor. CD16a / FCGR3A on human NK cells is a lysis receptor that mediates the direct killing of some virus infected and tumor cells, independent of antibody ligation.

存储条件: Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6~12 month

关键字: IMD 20 | FCG 3 | Fc fragment of IgG, low affinity IIIa, receptor | FCGR-3 | FCGR 3 | FCR 10 | CD-16 | IMD-20 | CD 16 | Fc gamma RIIIa | IGFR-3 | IGFR 3 | FCG-3 | FCR10 | CD16a

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