Ubiquitin Activating Enzyme E1/UBA1, Human, 重组蛋白 (His & GST) TMPY-02840
品牌 | 厂商性质 | 产地 | 货期 |
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TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | 价格 | 操作 |
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50 μg | ¥2,530.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Ubiquitin Activating Enzyme E1/UBA1 Protein, Human, Recombinant (His & GST)
描述: UBE1, also known as UBA1, belongs to the ubiquitin-activating E1 family. UBE1 gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. UBE1 catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. It also catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Defects in UBA1 can cause spinal muscular atrophy X-linked type 2 (SMAX2), also known as X-linked lethal infantile spinal muscular atrophy, distal X-linked arthrogryposis multiplex congenita or X-linked arthrogryposis type 1 (AMCX1). Spinal muscular atrophy refers to a group of neuromuscular disorders characterized by degeneration of the anterior horn cells of the spinal cord, leading to symmetrical muscle weakness and atrophy. SMAX2 is a lethal infantile form presenting with hypotonia, areflexia, and multiple congenital contractures.
存储条件: Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6~12 month
关键字: SMAX-2 | UBE 1 | CFAP-124 | GXP-1 | GXP 1 | CFAP 124 | SMAX 2 | UBE-1 | POC-20 | AMCX-1 | AMCX 1 | POC 20
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