CD44, Human, 重组蛋白 (hFc) TMPY-03530

Product Introduction
Bioactivity


英文名: CD44 Protein, Human, Recombinant (hFc)

描述: CD44 is a type I transmembrane protein and a member of the cartilage link protein family. It is involved in cell-cell and cell-matrix interactions and signal transduction. Several CD44 ligands have been identified. The most extensively characterized ligand for CD44 is hyaluronan, a component of the extracellular matrix. CD44 protein is expressed on the majority of immune cells. The binding of CD44 to hyaluronan is induced on T lymphocytes after activation by antigen and on monocytes after stimulation by inflammatory agents. Under inflammatory conditions, CD44 on endothelial cells presents hyaluronan to CD44 on activated T lymphocytes and mediates a rolling interaction under flow conditions. Perturbations of the hyaluronan-CD44 interaction at the plasma membrane by various antagonists result in attenuation of receptor tyrosine kinase and transporter activities and inhibition of tumor progression in vivo. CD44 is known to interact with the ezrin family (ERM family) members and form a complex that plays diverse roles within both normal and abnormal cells, particularly cancer cells. CD44 and ezrin and their respective complex have properties suggesting that they may be important in the process of tumour-endothelium interactions, cell migrations, cell adhesion, tumour progression and metastasis.

存储条件: Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6~12 month

关键字: CSPG-8 | MC-56 | MDU 3 | MDU 2 | CSPG 8 | MIC 4 | CDW 44 | CD44 molecule | MDU-3 | Indian blood group | MIC-4 | CDW-44 | MDU-2 | MC 56

CD44, Human, 重组蛋白 (hFc) TMPY-03530信息由TargetMol中国为您提供，如您想了解更多关于CD44, Human, 重组蛋白 (hFc) TMPY-03530报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途