Germinal Center Kinase/MAP4K2, Human, 重组蛋白 (His & GST) TMPY-04412

Product Introduction
Bioactivity


英文名: Germinal Center Kinase/MAP4K2 Protein, Human, Recombinant (His & GST)

描述: Mitogen-activated protein kinase kinase kinase kinase 2, also known as B lymphocyte serine/threonine-protein kinase, Germinal center kinase, MAPK/ERK kinase kinase kinase 2, MEK kinase kinase 2, Rab8-interacting protein, and MAP4K2, is cytoplasm and peripheral membrane protein that belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and STE2 subfamily. MAP4K2 contains one CNH domain and one protein kinase domain. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of the germinal center, where it may participate in B-cell differentiation. MAP4K2 can be activated by TNF-alpha and has been shown to specifically activate MAP kinases. It is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1 / MEKK1. MAP4K2 enhances MAP3K1 oligomerization, which may relieve amino-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. It may also play a role in the regulation of vesicle targeting or fusion.

存储条件: store at low temperatureLyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6~12 month

关键字: BL 44 | BL-44

Germinal Center Kinase/MAP4K2, Human, 重组蛋白 (His & GST) TMPY-04412信息由TargetMol中国为您提供，如您想了解更多关于Germinal Center Kinase/MAP4K2, Human, 重组蛋白 (His & GST) TMPY-04412报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途