三裂鼠尾草素 TMS1743
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
25 mg | 19103-54-9 | ¥4,360.00 | 询底价 |
10 mg | 19103-54-9 | ¥2,660.00 | 询底价 |
1 mL | 19103-54-9 | ¥1,350.00 | 询底价 |
50 mg | 19103-54-9 | ¥6,170.00 | 询底价 |
1 mg | 19103-54-9 | ¥389.00 | 询底价 |
100 mg | 19103-54-9 | ¥8,290.00 | 询底价 |
5 mg | 19103-54-9 | ¥1,620.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Salvigenin
描述: Salvigenin 是从鼠尾草中发现的一种多酚类天然产物,具有神经保护、抗肿瘤、免疫调节和细胞毒作用。
细胞实验: Upon establishing a non-effective dose of doxorubicin, and effective doses of eupatorin (100μM) and salvigenin (150μM) via MTT, morphological features of apoptosis were distinguished using DAPI staining and cell cycle blockage in the sub-G1 phase. Apoptosis was determined by annexin/ PI and western blotting. ROS levels and MMP were measured to show any role of mitochondria in apoptosis[1].
体外活性: Co-administration of flavonoids(eupatorin and salvigenin) with doxorubicin induced apoptosis via the mitochondrial pathway as mitochondrial membrane potential and ROS production were changed. Annexin/PI analysis demonstrated that apoptosis frequency was increased with the combination treatments in colon cancer cells. Finally, the combination of these flavonoids with doxorubicin increased the Bax/Bcl-2 ratio, caspase-3 expression and PARP cleavage[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 4.4 mg/mL (13.4 mM)
关键字: inhibit | Salvigenin | Apoptosis | immunomodulatory | ROS Kinase | Autophagy | Inhibitor | neuroprotective | antioxidant
相关产品: APG-2449 | ROS kinases-IN-2 | ROS-generating agent 1 | ROS kinases-IN-1 | Anti-inflammatory agent 64 | Methyl 12-methyltridecanoate | Crizotinib | Entrectinib | Merestinib | Taletrectinib
相关库: Anti-Inflammatory Traditional Chinese Medicine Compound Library | Tobacco Monomer Library | Selected Plant-Sourced Compound Library | Kinase Inhibitor Library | Inhibitor Library | Human Endogenous Metabolite Compound Library Plus | Anti-Cancer Active Compound Library | Traditional Chinese Medicine Monomer Library | Tyrosine Kinase Inhibitor Library | Miao medicine Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途