葫芦素 D TN1013

Product Introduction
Bioactivity


英文名: Cucurbitacin D

描述: Cucurbitacin D has anticancer effects, it induces apoptosis through caspase-3 and phosphorylation of JNK in hepatocellular carcinoma cells.

体外活性: Immunomodulating activities of Cucurbitacin D were investigated in macrophages. Cucurbitacin D could increase LPS-induced interleukin (IL)-1β production in culture supernatant of THP-1 cells, peritoneal exudate cells (PECs), bone marrow derived macrophages (BMDMs), and RAW264 cells. At the transcriptional level, Cucurbitacin D enhanced LPS-induced IL-1β mRNA expression through activation of ERK1/2 mitogen-activated protein kinases (MAPKs). At the posttranscriptional level, the activation of caspase-1 induced by Cucurbitacin D has also been demonstrated following treatment with a caspase-1 inhibitor and siRNA. Importantly, Cucurbitacin D has further been shown to induce inflammasome activation independent of ERK1/2 activation. Western blotting showed interaction of NOD-like receptor family, pyrin domain containing 3 (NALP3) and apoptosis-associated speck-like protein containing a caspase-activating and recruitment domain (ASC), suggesting activation of the inflammasome and a possible reason for activation of caspase-1[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Cucurbitacin D

相关产品: Aucubin | Nyasol | norbergenin | Flavoglaucin | Catalposide | Viscidulin II | IL-17A antagonist 1 | Lyn peptide inhibitor acetate | Sanggenone H | Menthone

葫芦素 D TN1013信息由TargetMol中国为您提供，如您想了解更多关于葫芦素 D TN1013报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途