丹参新酮 TN1023

Product Introduction
Bioactivity


英文名: Miltirone

描述: Miltirone 是存在于丹参中的一种天然产物，可作为中枢苯二氮受体部分激动剂，IC50值为 0.3 μM。

体外活性: Miltirone inhibited multidrug-resistant P-glycoprotein (P-gp)-overexpressing CEM/ADR5000 cells better than drug-sensitive CCRF-CEM wild-type cells, a phenomenon termed collateral sensitivity. Flow cytometric analyses revealed that Miltirone induced G2/M arrest and apoptosis. Furthermore, Miltirone stimulated reactive oxygen species (ROS) generation and mitochondrial membrane potential (MMP) disruption, which in turn induced DNA damage and activation of caspases and poly ADP-ribose polymerase (PARP). Downregulation of CCNB1 (cyclin B1) and CDC2 mRNA and upregulation of CDKN1A (p21) mRNA were in accord with Miltirone-induced G2/M arrest. Moreover, Miltirone decreased cell adherence to fibronectin. Molecular docking revealed that Miltirone bound to the ATP-binding site of IKK-β[1]

存储条件: store at low temperature,keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 25 mg/mL (88.53 mM)


关键字: Gamma-aminobutyric acid Receptor | inhibit | acid | γ-Aminobutyric acid Receptor | GABA Receptor | neurotransmission | GABA | γ-aminobutyric | Inhibitor | Miltirone

相关产品: CRTH2-IN-1 | Humantenmine | 2-Hydroxy-1-Methoxyaporphine | Isavuconazole | Germacrone | Tetrahydrocurcumin | MCH-1 antagonist 1 | Uniconazole | Lofemizole | Chamaechromone

相关库: PBCRBS Traditional Chinese Medicine Compound Library | Anti-Neurodegenerative Disease Compound Library | Anti-Parkinson's Disease Compound Library | Membrane Protein-targeted Compound Library | Neuronal Signaling Compound Library | Inhibitor Library | Traditional Chinese Medicine Monomer Library | Natural Product Library for HTS | Anti-COVID-19 Traditional Chinese Medicine Compound Library | Covalent Inhibitor Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途