缝籽木嗪甲醚 TN1032

Product Introduction
Bioactivity


英文名: Geissoschizine methyl ether

描述: Geissoschizine methyl ether 是从钩藤中发现的一种生物碱，是 Yokukansan 的主要活性成分，具有精神药物作用。它是一种有效的 5-羟色胺 A 受体激动剂，是 Yokukansan 改善攻击性和社交性的候选药物。

体外活性: To find the candidate ingredients, we examined competitive binding assay and [(35)S] guanosine 5'-O-(3-thiotriphosphate) (GTPγS) binding assay of seven major alkaloids in UH using Chinese hamster ovary cells expressing 5-HT(1A) receptors artificially. Only Geissoschizine methyl ether (GM) among seven alkaloids potently bound to 5-HT(1A) receptors and acted as a partial agonist. This in vitro result on GM was further demonstrated in the socially isolated mice. As did YKS and UH, GM ameliorated the isolation-induced increased aggressiveness and decreased sociality, and the effect was counteracted by coadministration of WAY-100635[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 11 mg/mL (30.02 mM)


关键字: 5-HT Receptor | Inhibitor | inhibit | 5-hydroxytryptamine Receptor | Serotonin Receptor | Geissoschizine methyl ether

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相关库: Anti-Neurodegenerative Disease Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Human Metabolite Library | GPCR Compound Library | Traditional Chinese Medicine Monomer Library | Natural Product Library for HTS | Miao medicine Compound Library | RO5 Drug-like Natural Product Library | Bioactive Compound Library

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