格兰地新 TN1037

Product Introduction
Bioactivity


英文名: Groenlandicine

描述: Groenlandicine 是来自黄连的一种原小檗碱生物碱，能诱导拓扑异构酶 I 介导的 DNA 裂解。它对人类重组醛糖还原酶(HRAR)具有中度的抑制作用，IC50值为 154.2 μM。

体外活性: Isolated alkaloids from Coptis chinensis Franch. The compounds were identified as berberine, columbamine, Groenlandicine, jatrorrhizine, magnoflorine, corydaldine and ferulic acid methylester. Then measured their bitter degree based on the electronic tongue and evaluated the antibacterial. The results based on the Electronic Tongue showed that berberine, columbamine, Groenlandicine and jatrorrhizine have higher bitter degree than magnoflorine and corydaldine. And they also appeared better antibacterial activity on E. coli and S. aureus. The correlation coefficients between bitter degree and the two bacteria antibacterial activity were 0.983 and 0.911[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 1.83 mg/mL (5.69 mM)


关键字: Topoisomerase | Groenlandicine | inhibit | Inhibitor

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相关库: Anti-Tumor Natural Product Library | Anti-Neurodegenerative Disease Compound Library | Bioactive Compounds Library Max | Chinese Pharmacopoeia Natural Product Library | Inhibitor Library | Alkaloid Natural Product Library | DNA Damage & Repair Compound Library | Natural Product Library for HTS | RO5 Drug-like Natural Product Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途