盖尔格拉文 TN1038

Product Introduction
Bioactivity


英文名: Galgravin

描述: Galgravin 是望春花中的一种天然产物，具有抗炎和体外细胞毒活性，能诱导白血病细胞凋亡。

体外活性: This approach resulted in the isolation and characterization of eight tetrahydrofuran neolignans: calopeptin (1), machilin-G (2), machilin-I (3), aristolignin (4), nectandrin A (5), veraguensin (6), ganschisandrin (7), and Galgravin (8). Different assays were conducted to evaluate their cytotoxic activities and to determine the possible mechanism(s) related to the activity displayed against human leukemia cells. The most active compounds 4, 5 and 8 gave IC50 values of 14.2 ± 0.7, 16.9 ± 0.8 and 16.5 ± 0.8 μg/mL, respectively, against human leukemia (HL-60) tumor cells. Moreover, these compounds induced specific apoptotic hallmarks, such as plasma membrane bleb formation, nuclear DNA condensation, specific chromatin fragmentation, phosphatidyl-serine exposure on the external leaflet of the plasma membrane, cleavage of PARP as well as mitochondrial damage, which as a whole could be related to the intrinsic apoptotic pathway.

存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 9 mg/mL (24.16 mM)


关键字: inhibit | Inhibitor | Galgravin | Apoptosis

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相关库: Anti-Tumor Natural Product Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Bioactive Compounds Library Max | Chinese Pharmacopoeia Natural Product Library | Traditional Chinese Medicine Monomer Library | Hematonosis Compound Library | Natural Product Library for HTS | Apoptosis Compound Library | Traditional Mongolian Medicine Compound Library | RO5 Drug-like Natural Product Library

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