脱氧鬼臼毒素 TN1087

Product Introduction
Bioactivity


英文名: Deoxypodophyllotoxin

描述: Deoxypodophyllotoxin 是从桃儿七根茎分离的一种木酚素，是鬼臼毒素衍生物，具有抗有丝分裂和抗病毒特性。它是血管生成抑制剂，作为靶向微管药物，在肿瘤学中具有重大影响。它引起 DRG 神经元细胞内 Ca2+浓度增加，诱导细胞自噬和凋亡。

体外活性: Deoxypodophyllotoxin (DPT) induced both apoptosis and autophagy via production of mitochondrial reactive oxygen species (ROS).?DPT suppressed the PI3K/AKT/mTOR signaling cascades to lead autophagy process, resulting from conversion of light chain 3-I (LC3-I) into LC3-II and acidic vesicular organelles (AVOs) formation.?Even if DPT-induced ROS were occurred in both apoptosis and autophagy, inhibition of ROS generation enhanced cell viability.?Otherwise, 3-methyladeine (3-MA) impeding on autophagy accelerated an apoptotic response caused by DPT.?Therefore, these findings suggest that DPT triggers cytoprotective autophagy against cytotoxic apoptosis[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 55 mg/mL (138.05 mM)


关键字: Microtubule/Tubulin | inhibit | Inhibitor | Deoxypodophyllotoxin | Apoptosis | Autophagy

相关产品: Apitolisib | Lomustine | SSE15206 | MI-136 | Ganetespib | Flavokawain A | (E)-Methyl 4-coumarate | NSC 15364 | Bortezomib | PRIMA-1

相关库: Microtubule-Targeted Compound Library | Selected Plant-Sourced Compound Library | Inhibitor Library | Anti-Cancer Active Compound Library | Traditional Chinese Medicine Monomer Library | Natural Product Library for HTS | NO PAINS Compound Library | Covalent Inhibitor Library | Natural Product Library | Anti-Infection Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途