O-去甲荷叶碱 TN1092

Product Introduction
Bioactivity


英文名: O-Nornuciferine

描述: O-Noruciferine 是分离自荷叶的卟啉型生物碱，是有效的 hERG 通道抑制剂。

体外活性: In an in vitro screening of herbal materials for hERG blockers using an automated two-microelectrode voltage clamp assay on Xenopus oocytes, an alkaloid fraction of Nelumbo nucifera Gaertn. (lotus) leaves induced ???50% of hERG current inhibition at 100 μg/mL. Chromatographic separation resulted in the isolation and identification of (-)-asimilobine, 1, nuciferine, 2, O-Nornuciferine, 3, N-nornuciferine, 4, and liensinine, 5. In agreement with in silico predicted ligand-target interactions, 2, 3, and 4 revealed distinct in vitro hERG blockages measured in HEK293 cells with IC50 values of 2.89, 7.91, and 9.75 μM, respectively.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (177.71 mM)


关键字: Inhibitor | Potassium Channel | O-Nornuciferine | KcsA | inhibit | ONornuciferine | O Nornuciferine

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