二叶草素 TN1103

Product Introduction
Bioactivity


英文名: Diphyllin

描述: Diphyllin 是一种从Justicia procumbens 中分离的芳基萘木脂素，是HIV-1的有效抑制剂，IC50 为 0.38 μM。它是V-ATPase 抑制剂，IC50值为 17 nM，可抑制人破骨细胞中的溶酶体酸化。它抑制NO 产生，IC50值为 50 μM ，具有抗癌和抗炎活性。

体外活性: The in vitro inhibitory effects of these compounds were evaluated on the production of nitric oxide (NO) and cytokines (tumor necrosis factor (TNF)-alpha and interleukin (IL)-12), from LPS/IFN-gamma activated murine peritoneal macrophages. The results indicated that the 50% inhibition concentration (IC(50)) values of NO production from activated peritoneal macrophages by compounds 1-4 were 100, 25, 12.5 and 50 microM, respectively. In parallel, these dilutions were approximately inhibited in a similar manner to that observed for cytokines (TNF-alpha, and IL-12) production. On the other hand, at 100 microM concentration compounds 3 and 4 showed 50% inhibition of NO production from peritoneal macrophages that had been pre-activated with LPS/IFN-gamma for 24h, whereas compounds 1 and 2 inhibited only about 20 and 10%, respectively.

存储条件: keep away from direct sunlight,store under nitrogenPowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 3.8 mg/mL (10 mM)


关键字: HIV-1 | lignan | Proton Pump | Influenza Virus | HIV | Human immunodeficiency virus | Diphyllin | Inhibitor | cytotoxicity | influenza | arylnaphthalene | VSV | antiviral | virus | inhibit

相关产品: Chlorpropamide | Lasiodiplodin | Prilocaine | Rostafuroxin | Cycloartane-3,24,25-triol | FR-167356 | Chloroprocaine hydrochloride | trans-Aconitic acid | Goniothalamin | BTS

相关库: Wnt/Hedgehog/Notch Compound Library | Membrane Protein-targeted Compound Library | Chinese Pharmacopoeia Natural Product Library | Inhibitor Library | Anti-Cancer Active Compound Library | Traditional Chinese Medicine Monomer Library | Miao medicine Compound Library | NO PAINS Compound Library | Anti-Infection Compound Library | Anti-infective Natural Product Library

二叶草素 TN1103信息由TargetMol中国为您提供，如您想了解更多关于二叶草素 TN1103报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途