原花青素 A2 TN1132

Product Introduction
Bioactivity


英文名: Procyanidin A2

描述: Procyanidin A2 是一种具有抗癌、抗氧化、抗菌和抗炎活性的黄酮类天然产物，存在于蔓越莓和越橘中。

体外活性: Here we evaluated Procyanidin A2 as a means of modulating CCL26 production and investigated interactions with the known inflammation modulator, Interferon γ (IFNγ). We used the human lung epithelial cell line A549 and optimized the conditions for inducing CCL26. Cells were exposed to a range of Procyanidin A2 or IFNγ concentrations for varied lengths of time prior to an inflammatory insult of interleukin-4 (IL-4) for 24 h. An enzyme-linked immunosorbent assay was used to measure CCL26 production. Exposing cells to 5 μM Procyanidin A2 (prior to IL-4) reduced CCL26 production by 35% compared with control. Greatest inhibition by Procyanidin A2 was seen with a 2 h exposure prior to IL-4, whereas IFNγ inhibition was greatest at 24 h. Concomitant incubation of Procyanidin A2 and IFNγ did not extend the inhibitory efficacy of Procyanidin A2[1]

存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 100 mg/mL (173.46 mM)


关键字: Procyanidin A 2 | Bacterial | Procyanidin A-2 | Inhibitor | Procyanidin A2 | inhibit

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相关库: Angiogenesis related Compound Library | Cytokine Inhibitor Library | Bioactive Compounds Library Max | Chinese Pharmacopoeia Natural Product Library | Traditional Chinese Medicine Monomer Library | Apoptosis Compound Library | Metabolism Compound Library | Flavonoid Natural Product Library | Traditional Mongolian Medicine Compound Library | Anti-Infection Compound Library

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