原花青素B4 TN1151

Product Introduction
Bioactivity


英文名: Procyanidol B4

描述: Procyanidin B4 reveals significant antioxidant activity

体外活性: Aimed to isolate and purify the proanthocyanidins from lotus seed skin by acetone extraction and rotary evaporation, identify their chemical structures by HPLC-MS-MS and NMR, and further investigate the antioxidant properties of the extract purified by macroporous resin (PMR) from lotus seed skin both in vitro and in vivo. The results showed that PMR mainly contained oligomeric proanthocyanidins, especially dimeric procyanidin B1 (PB1), procyanidin B2 and Procyanidin B4. Although it had limited ability to directly scavenge radicals in vitro, PMR could significantly enhance the expressions of antioxidant proteins via activation of nuclear factor-E2-related factor 2 (Nrf2)-antioxidant response element (ARE) pathway in HepG2 cells. Molecular data revealed that PB1, a major component in PMR, stabilized Nrf2 by inhibiting the ubiquitination of Nrf2, which led to subsequent activation of the Nrf2-ARE pathway, including the enhancements of Nrf2 nuclear translocation, Nrf2-ARE binding and ARE transcriptional activity. Moreover, the in vivo results in high fat diet-induced mice further verified the powerful antioxidant property of PMR[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Procyanidol B4 | Procyanidol B-4

相关产品: Garcinone D | AEM1 | Danshensu | Latifolin | Sappanone A | Luteolin | 4-hydroxyphenylacetic acid | Kinsenoside | Hinokitiol | CDDO-Im

原花青素B4 TN1151信息由TargetMol中国为您提供，如您想了解更多关于原花青素B4 TN1151报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途