聚孔酸C TN1153

Product Introduction
Bioactivity


英文名: Polyporenic acid C

描述: Polyporenic acid C 是从茯苓中分离出的一种羊毛甾烷型三萜，可通过死亡受体介导的凋亡途径诱导细胞凋亡，有用于肺癌的研究潜力。

体外活性: Polyporenic acid C (PPAC) significantly reduced cell proliferation via induction of apoptosis as evidenced by sub-G1 analysis, annexin V-FITC staining, and increase in cleavage of procaspase-8, -3, and poly(ADP-ribose)-polymerase (PARP). However, unlike our previously reported lanostane-type triterpenoid, pachymic acid, treatment of cells with PPAC was not accompanied by disruption of mitochondrial membrane potential and increase in cleavage of procaspase-9. Further, PPC-induced apoptosis was inhibited by caspase-8 and pan-caspase inhibitors but not by a caspase-9 inhibitor.

存储条件: keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 60 mg/mL (124.3 mM)


关键字: cell | Polyporenic acid C | Apoptosis | inhibit | Inhibitor | lung | cancer | NSCLC

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相关库: Anti-Liver Cancer Compound Library | Anti-Ovarian Cancer Compound Library | Inhibitor Library | Kinase Inhibitor Library | Traditional Chinese Medicine Monomer Library | Anti-Cancer Active Compound Library | Metabolism Compound Library | Microbial Natural Product Library | Glycolysis Compound Library | NO PAINS Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途