1-脱氢-6-姜酮 TN1171

Product Introduction
Bioactivity


英文名: 6-Dehydrogingerdione

描述: 1-Dehydro-6-gingerdione is a 5-HT1A receptor partial agonist.

体外活性: The relative antioxidant potencies of ginger compounds decreased in similar order of 1-Dehydro-6-gingerdione, hexahydrocurcumin>6-shogaol>6-dehydroshogaol in both 1,1-diphenyl-2-picyrlhydrazyl (DPPH) radical-scavenging and trolox equivalent antioxidant capacity (TEAC) assays. All tested compounds could attenuate lipopolysaccharide (LPS)-elicited increase of prostaglandin E2 (PGE(2)) in murine macrophages (RAW 264.7) in a concentration-dependent manner but hexahydrocurcumin of 7μM and 6-shogaol of 7μM. The strongest inhibitory effect was observed for 6-dehydroshogaol and 6-shogaol at 14μM with the inhibition of 53.3% and 48.9%, respectively. Furthermore, both 6-dehydroshogaol and 1-Dehydro-6-gingerdione significantly suppressed the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins in a concentration-dependent fashion.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: 6-Dehydrogingerdione | 6 Dehydrogingerdione | 6Dehydrogingerdione

相关产品: Capillarisin | EX-A5758 | Dunnianol | Xanthoxyletin | Nyasol | 5α-Hydroxycostic acid | S-Methylisothiourea sulfate | 2-Iminobiotin | Cyclo(L-Pro-L-Val) | iNOS-IN-14

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