13-甲基小檗碱 TN1189
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
50 mg | 54260-72-9 | ¥3,180.00 | 询底价 |
25 mg | 54260-72-9 | ¥2,150.00 | 询底价 |
1 mL | 54260-72-9 | ¥960.00 | 询底价 |
100 mg | 54260-72-9 | ¥4,680.00 | 询底价 |
10 mg | 54260-72-9 | ¥1,280.00 | 询底价 |
5 mg | 54260-72-9 | ¥868.00 | 询底价 |
1 mg | 54260-72-9 | ¥368.00 | 询底价 |
Product Introduction
Bioactivity
英文名: 13-Methylberberine chloride
描述: 13-Methylberberine chloride 是一种黄连素类似物,可增加 IL-12 的产生,并在 LPS 激活的巨噬细胞转录后抑制 iNOS 的表达,具有抗脂肪和抗肿瘤作用。
体外活性: We screened 11 protoberberine and 2 benzophenanthridine alkaloids for their anti-adipogenic effects on 3T3-L1 adipocytes and found that 13-Methylberberine exhibited the most potent activity. 13-Methylberberine down-regulated the expression of the main adipocyte differentiation transcription factors, peroxisome proliferator-activated receptor gamma (PPARγ) and CCAAT enhancer binding protein alpha (C/EBPα±), as well as their target genes. PPARγ, C/EBPα±, and sterol regulatory element binding protein 1 (SREBP-1) protein levels were reduced, and this lipid-reducing effect was attenuated by an AMP-activated protein kinase (AMPK) inhibitor, indicating that the effect of this compound requires the AMPK signaling pathway. Decreased Akt phosphorylation suggested reduced de novo lipid synthesis. C-13 methyl substitution of berberine increased its accumulation in treated cells, suggesting that 13-Methylberberine has improved absorption and higher accumulation compared to berberine.
存储条件: keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 10 mg/mL (25.92 mM)
关键字: inhibit | Inhibitor | 13 Methylberberine chloride | 13-Methylberberine Chloride | 13Methylberberine chloride | Interleukin Related | 13-Methylberberinium
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途