27-脱氧升麻亭 TN1222

Product Introduction
Bioactivity


英文名: 26-Deoxyactein

描述: 23-epi-26-Deoxyactein (27-Deoxyactein) 是一种黑升麻中的主要成分，能够阻止 TCDD 诱导的成骨细胞的损伤。它对 AhR，CYP1A1 和 ERK 的水平升高具有抑制作用。

体外活性: Black cohosh rhizomes were extracted with methanol/water and fractionated by solvent-solvent partitioning to yield three fractions: hexane, ethyl acetate and water. The ethyl acetate fraction displayed the highest potency in two cell-based assays, growth inhibition and cell cycle analysis. This fraction inhibited growth of both the ER+ MCF7 and ER-MDA-MB-453 human breast cancer cell lines with IC50 values of about 20 and 10 micro g/ml, respectively. It also induced cell cycle arrest at G1 when tested at 30 micro g/ml and at G2/M at 60 micro g/ml in MCF7 cells. This suggests that the extract contains a mixture of components with the more active (or more abundant) causing G1 arrest and the less active causing G2/M arrest. We then examined specific components in this extract. The triterpene glycoside fraction obtained by polyamide column chromatography, and the specific triterpene glycosides actein, 23-epi-26-Deoxyactein and cimiracemoside A, inhibited growth of the MCF7 human breast cancer cells and induced cell cycle arrest at G1[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 70 mg/mL (105.93 mM)


关键字: 26-Deoxyactein | Inhibitor | 26Deoxyactein | inhibit | 26 Deoxyactein

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相关库: Anti-Inflammatory Traditional Chinese Medicine Compound Library | Anti-Breast Cancer Compound Library | Bioactive Compounds Library Max | Chinese Pharmacopoeia Natural Product Library | Kinase Inhibitor Library | Traditional Chinese Medicine Monomer Library | Natural Product Library for HTS | Anti-Pancreatic Cancer Compound Library | Traditional Mongolian Medicine Compound Library | NO PAINS Compound Library

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