25S-牛膝甾酮 TN1228

Product Introduction
Bioactivity


英文名: 25S-Inokosterone

描述: 25S-Inokosterone exhibits potent inhibition against TNF-expression levels in A23187 plus phorbol-myrisrate acetate-induced RBL-2H3 cells. 25S-Inokosterone has excellent anti-atopy activity, thus 25S-Inokosterone could be used to a large range of functional anti-atopy cosmetics.

体外活性: Three compounds were isolated from the subfraction 5 through the repeated prep- high performance liquid chromatography column chromatography. According to the results of physico-chemical and spectroscopic data including NMR and MS, the chemical structures of the compounds were determined as ecdysterone (1), 25S-Inokosterone (2), and 25R-inokosterone (3). Three phytoecdysones were showed weak inhibitory activity for thymus and activation-regulated chemokine expression levels in tumor necrosis factor (TNF)-α± plus IFN-γ induced HaCaT cells, respectively. However, those compounds 1-3 were exhibited the most potent inhibition (80??95% at 200 μg/mL) against TNF-α± expression levels in A23187 plus phorbol-myrisrate acetate-induced RBL-2H3 cells.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: 25S-Inokosterone | 25S Inokosterone | 25SInokosterone

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