3'-甲氧基大豆黄素 TN1254

Product Introduction
Bioactivity


英文名: 3'-Methoxydaidzein

描述: 3'-Methoxydaidzein 是一种异黄酮和 Sodium Channel 双重抑制剂。3'-Methoxydaidzein 对NaV1.7、NaV1.8 和 NaV1.3有抑制作用，IC50 分别为 181 nM、397 nM 和 505 nM。 3'-Methoxydaidzein 对胶原诱导的血小板聚集具有特异性，IC50值分别为12.3和61.5µM。。3'-Methoxydaidzein 通过抑制电压门控钠通道发挥镇痛作用。 3'-Methoxydaidzein 具有抗氧化活性和抗血小板聚集活性。

体外活性: 3'-Methoxydaidzein, their antioxidant activities were investigated and compared with butylated hydroxyluene (BHT) and α±-tocopherol. The results showed that 3'-Methoxydaidzein had antioxidant activity. When the individual components (0.02%) were mixed with 0.02% BHT, or 0.02% α±-tocopherol, their protection factor was increased, but there was no synergistic effect. When the individual component had 4 ppm added Fe3+, 3'-Methoxydaidzein had antioxidant activity. Their antioxidant activities were tested by an oxidative stability instrument (OSI) at 100°C.[1]

体内活性: 3'-Methoxydaidzein shows strong analgesic potential without inducing addiction through inhibiting subtypes NaV1.7, NaV1.8 and NaV1.3 with the IC50 of 181 ± 14, 397 ± 26, and 505 ± 46 nmol·L-1, respectively, providing a promising compound or parent structure for the treatment of pain pathologies. This study reveals a pain-alleviating mechanism of dietary isoflavones and may provide a convenient avenue to alleviate pain.[2]

存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: 3'Methoxydaidzein | 3'-Methoxydaidzein | 3' Methoxydaidzein

相关产品: BmK-M1 | KT-362 fumarate | Lidocaine hydrochloride | Rimeporide hydrochloride | Mambalgin-3 | Dimethyl lithospermate B | Wilfordine | BI 01383298 | Dyclonine hydrochloride | Jingzhaotoxin-34

相关库: Membrane Protein-targeted Compound Library | Rare Natural Product Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途